Table 8.
Demographic, clinical and therapeutic characteristics of Depressives patients according to the MTHFR C766T genotypes
| MTHFR | p | |||
|---|---|---|---|---|
| CC | CT | TT | ||
| Age | 45.37 ± 13.036 | 42.16 ± 14.132 | 45.09 ± 13.287 | 0.261 |
| BMI | 27.127 ± 5.992 | 26.8113 ± 5.992 | 27.965 ± 5.201 | 0.685 |
| Gender | ||||
| Man | 43 (47.2 %) | 37 (40.7 %) | 11 (12.1 %) | 0.707 |
| Women | 62 (53 %) | 43 (36.8 %) | 12 (10.2 %) | |
| Alcohol | ||||
| Yes | 12 (28.6 %) | 26 (61.9 %) | 4 (9.5 %) | 0.001 |
| No | 19 (11.6) | 52 (31.7 %) | 93 (56.7 %) | |
| Drugs | ||||
| Yes | 5 (29.4 %) | 12 (70.6 %) | (0 %)0 | 0.013 |
| No | 100 (52.4 %) | 68 (35.6 %) | 23 (12 %) | |
| Smoker | ||||
| Yes | 28 (41.2 %) | 34 (50 %) | 6 (8.8 %) | 0.058 |
| No | 77 (55 %) | 46 (32.9 %) | 17 (12.1 %) | |
| Suicide attempts | ||||
| Yes | 9 (32.1 %) | 14 (50 %) | 5 (17.9 %) | 0.099 |
| No | 96 (53.3 %) | 66 (36.7) | 18 (10 %) | |
| Characteristics | ||||
| Psychotic | 19 (45.2 %) | 16 (38.1 %) | 7 (16.7 %) | 0.705 |
| Melancholic | 71 (51.1 %) | 55 (39.6 %) | 13 (9.3 %) | |
| Atypical | 15 (55.6 %) | 9 (33.3 %) | 3 (11.1 %) | |
| Severity 2 | ||||
| Low | 12 (36.4 %) | 14 (42.4 %) | 7 (21.2 %) | 0.052 |
| Medium | 75 (55.1 %) | 52 (38.2 %) | 9 (6.7 %) | |
| Severe | 18 (46.2 %) | 14 (35.9 %) | 7 (17.9 %) | |
| Anxiety associated | ||||
| Yes | 60 (54.1) | 39 (35.1) | 12 (10.8) | 0.522 |
| No | 45 (46.4) | 41 (42.3) | 11 (11.3) | |
| Type of anxiety | ||||
| Panic | 23 (67.7 %) | 10 (29.4) | 1 (2.9 %) | 0.129 |
| General anxiety | 37 (48.1 %) | 30 (38.9 %) | 10 (13 %) | |
| Obsessive compulsive | 4 (100 %) | 0 | 0 | |
| Panic and general anxiety | 0 | 1 (100 %) | 0 | |
| Personality disorders | ||||
| No | 39 (50 %) | 32 (41.1 %) | 7 (8.9 %) | 0.702 |
| Yes | 66 (50.8 %) | 48 (36.9 %) | 16 (12.3 %) | |
| Cluster | ||||
| Cluster A | 1 (25 %) | 2 (50 %) | 1 (25 %) | 0.818 |
| Cluster B | 18 (48.7 %) | 15 (40.5 %) | 4 (10.8 %) | |
| Cluster C | 10 (55.6 %) | 6 (33.3) | 2 (11.1 %) | |
| Adaptation | ||||
| No | 27 (54 %) | 19 (38 %) | 4 (8 %) | 0.662 |
| Almost | 44 (45.4 %) | 40 (41.2 %) | 13 (13.4 %) | |
| Better | 34 (55.8 %) | 21 (34.4 %) | 6 (9.8 %) | |
| Treatment | ||||
| No | 28 (54.9 %) | 18 (35.3 %) | 5 (9.8 %) | 0.806 |
| TCA | 19 (45.2 %) | 16 (38.1 %) | 7 (16.7 %) | |
| SIRS | 48 (51.1 %) | 37 (39.3 %) | 9 (9.6 %) | |
| Atypical | 8 (50 %) | 6 (37.5 %) | 2 (12.5 %) | |
| TCA + SIRS | 2 (33.3 %) | 4 (66.7 %) | 0 | |
| Antidepressor | ||||
| Amitriptyline | 10 (40 %) | 11 (44 %) | 4 (16 %) | 0.557 |
| Clomipramine | 11 (52.4 %) | 7 (33.3 %) | 3 (14.3 %) | |
| Escitalopram | 1 (14.3 %) | 4 (57.1 %) | 2 (28.6 %) | |
| Fluoxétine | 38 (56.7 %) | 23 (34.3 %) | 6 (9 %) | |
| Paroxétine | 9 (56.3 %) | 6 (37.5 %) | 1 (6.2 %) | |
| Sertraline | 2 (40 %) | 3 (60 %) | 0 | |
SIRS selective inhibitors of serotonin reuptake, TCA tricyclic antidepressant, Atypical venlafaxine, milnacipran