Table 3.
Molecular functions upregulated and downregulated as derived from DAVID algorithm based on proteins significantly differing in abundance by spectral counts and/or peak area in Sp2-cKO mice
| Molecular functions altered in Sp2-cKO
| |||||
|---|---|---|---|---|---|
| Pathway | Genes | p value | Fold change in Sp2-cKO | Fisher exact | Direction in KO |
| Ribonucleotide binding | 16 | 2.70E−03 | +2.2 | 1.20E−03 | Upregulated |
| Purine nucleotide binding | 16 | 4.00E−03 | +2.2 | 1.80E−03 | Upregulated |
| RNA binding | 9 | 4.10E−03 | +3.4 | 1.20E−03 | Upregulated |
| Purine nucleoside binding | 12 | 3.30E−02 | +2 | 1.60E−02 | Upregulated |
| Ligase activity, forming carbon-nitrogen bonds | 4 | 3.90E−02 | +5.2 | 7.10E−03 | Upregulated |
| Hydrolase activity, acting on acid anhydrides | 7 | 4.00E−02 | +2.7 | 1.40E−02 | Upregulated |
| Oxygen transporter activity | 3 | 1.40E−03 | −52.8 | 2.10E−05 | Downregulated |
| Purine nucleoside binding | 17 | 4.10E−03 | −2.1 | 1.80E−03 | Downregulated |
| Protein transporter activity | 4 | 4.60E−03 | −11.7 | 3.70E−04 | Downregulated |
| Purine nucleotide binding | 19 | 4.80E−03 | −2 | 2.30E−03 | Downregulated |
| Heme binding | 5 | 6.20E−03 | −6.7 | 8.70E−04 | Downregulated |
| Ribonucleotide binding | 18 | 7.30E−03 | −1.9 | 3.60E−03 | Downregulated |
| Hydrolase activity, acting on acid anhydrides | 9 | 1.70E−02 | −2.7 | 6.20E−03 | Downregulated |
| Ligase activity, forming phosphoric ester bonds | 2 | 2.00E−02 | −96.9 | 1.60E−04 | Downregulated |
| RNA binding | 9 | 2.00E−02 | −2.6 | 7.40E−03 | Downregulated |
| Phosphoprotein binding | 2 | 8.80E−02 | −21.5 | 3.80E−03 | Downregulated |