Table 4.
The comparisons of characteristics among LEPR gene in acromegalic patients and controls
| Patients (n=44) | Controls (n=30) | |||||
|---|---|---|---|---|---|---|
| GG | GA | AA | GG | GA | AA | |
| BMI (kg/m2) | 28.00±1.62 | 29.60±4.91 | 29.19±3.20 | 25.86±3.17 | 24.71±3.57 | 26.74±4.41 |
| SBP (mmHg) | 134.00±5.47 | 132.11±13.15 | 133.64±12.06 | 120.00±14.90 | 116.67±16.76 | 126.00±23.02 |
| DBP (mmHg) | 82.00±4.47 | 79.47±7.05 | 84.55±5.22 | 77.00±9.48 | 73.33±11.75 | 82.00±8.36 |
| FG (mg/dl) | 113.68±33.72 | 110.90±24.69 | 111.77±29.73 | 95.19±13.59 | 93.90±11.68 | 97.52±6.10 |
| TC (mg/dl) | 210.12±36.16 | 189.96±51.50 | 173.81±20.43 | 189.13±41.06 | 198.31±43.27 | 226.88±37.40 |
| TG (mg/dl) | 131.80±96.00 | 138.18±85.04 | 101.14±48.46 | 122.05±55.36 | 117.10±60.78 | 125.34±39.68 |
| HDL (mg/dl) | 64.44±14.97 | 53.76±11.89 | 54.10±14.94 | 53.52±11.86 | 51.05±15.48 | 60.82±18.89 |
| LDL (mg/dl) | 119.76±24.07 | 109.36±42.50 | 99.70±20.78 | 111.17±38.60 | 123.94±37.18 | 141.16±34.25 |
| GH (ng/l) | 2.82±2.22 | 1.22±0.91 | 1.86±1.62 | 0.52±1.08 | 0.24±0.34 | 0.40±0.45 |
| IGF-1 (ng/l) | 240.60±84.30 | 293.21±154.91 | 382.08±174.24 | 161.00 | 154.50±38.21 | 161.84±61.12 |
| IGFBP3 (μg/l) | 4.67±0.99 | 4.86±1.62 | 5.78±1.17 | 4.38±0.63 | 4.10±1.36 | 3.98±1.24 |
| Right cIMT(mm) | 0.86±0.15 | 0.76±0.14 | 0.73±0.15 | 0.67±0.11 | 0.76±0.17 | 0.65±0.12 |
| Left cIMT (mm) | 0.94±0.20 a | 0.80±0.20 | 0.74±0.13 a | 0.69±0.11 | 0.76±0.22 | 0.67±0.09 |
| Leptin (ng/ml) | 11.20±9.51 | 8.40±5.78 | 9.02±5.00 | 6.85±4.32 | 8.43±4.78 | 8.63±5.68 |
a:
In each line, the difference between the means with same letters are significant, p<0.05 (Mann-Whitney U test)