Table 2.

Multivariate Linear Regression Analysis

Independent Predictors	Univariate Analysis				Multivariate Analysis
	Beta Coefficient	Standard Error	St. Beta	p Value	Beta Coefficient	Standard Error	St. Beta	p Value
Dependent Variable: Cold-Induced Change in Whole-Body FFA Oxidation
BAT volume (ml)	0.027	0.0008	0.703	0.005	0.028	0.011	0.727	0.036
Age (years)	−0.032	0.0029	−3.04	0.290	−0.031	0.034	0.323	0.301
Body fat (%)	−0.121	0.055	−0.539	0.047	−0.060	0.070	−0.265	0.415
Dependent Variable: Cold-Induced Change in Whole-Body Lipolysisa
BAT volume (ml)	0.039	0.013	0.643	0.010	0.050	0.020	0.820	0.033
Age (years)	−0.038	0.038	−0.266	0.338	0.004	0.041	0.028	0.925
Body fat (%)	−0.103	0.073	−0.365	0.181	0.063	0.103	0.222	0.554
Dependent Variable: Cold-Induced Change in Total TG-FFA Cycling
BAT volume (ml)	0.095	0.033	0.630	0.014	0.159	0.045	1.062	0.006
Age (years)	−0.106	0.098	−0.297	0.302	−0.055	0.092	−0.594	0.565
Body fat (%)	−0.133	0.198	−0.191	0.512	0.479	0.226	0.686	0.061
Dependent Variable: Cold-Induced Change in Adipose Tissue Insulin Sensitivityb
BAT volume (ml)	0.523	0.240	0.550	0.052	0.258	0.364	0.271	0.496
Age (years)	−1.105	0.681	−0.439	0.134	−0.068	0.929	−0.027	0.944
Body fat (%)	−2.656	1.124	−0.580	0.038	−1.686	1.955	−0.368	0.411

FFA, free fatty acid; BAT, brown adipose tissue; TG, triglyceride.

^aExpressed as glycerol rate of appearance.

^bAdipose tissue insulin sensitivity was calculated as the percent suppression in palmitate rate of appearance with insulin.