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Association between UGT1A1 genotype and irinotecan toxicities
| Toxicities | Wild-type (n = 398), n (%) | Heterozygous (n = 327), n (%) | Homozygous (n = 70), n (%) |
|---|---|---|---|
| First-cycle neutropenia | |||
| Grade ≥1 | 209 (52.5) | 199 (60.9) | 42 (60.0) |
| Grade ≥3 | 69 (17.3) | 83 (25.4) | 20 (28.6) |
| Neutropenia | |||
| Grade ≥1 | 311 (78.1) | 266 (81.3) | 55 (78.6) |
| Grade ≥3 | 178 (44.7) | 177 (54.1) | 40 (57.1) |
| All adverse events | |||
| Grade ≥1 | 383 (96.2) | 321 (98.2) | 68 (97.1) |
| Grade ≥3 | 229 (57.5) | 223 (68.2) | 48 (68.6) |
