Table 6.
Multivariate predictors of treatment-related grade ≥3 neutropenia
| Neutropenia | |||
|---|---|---|---|
| OR | (95 % CI) | p value* | |
| UGT1A1 genotype (wild-type vs heterozygous) | 1.67 | 1.16–2.42 | 0.0060 |
| UGT1A1 genotype (wild-type vs homozygous) | 2.22 | 1.22–4.02 | 0.0088 |
| Age (years) (<70 vs ≥70) | 1.77 | 1.24–2.53 | 0.0017 |
| Sex (male vs female) | 1.38 | 0.97–1.95 | 0.0726 |
| Coelomic fluid (absent vs present) | 1.84 | 1.05–3.25 | 0.0343 |
| Starting dose reduction (reduction vs non-reduction) | 1.53 | 1.08–2.18 | 0.0176 |
UGT UDP-glucuronosyltransferase, OR odds ratio, CI confidence interval
* Chi-squared test