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. 2016 Jan 21;21:773–782. doi: 10.1007/s10147-016-0952-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Comparison of individual enzalutamide C_max and AUC_∞ during single-dosing. ^aPhase I, open-label, dose-escalation safety and pharmacokinetic study of enzalutamide in patients with CRPC conducted overseas [19]