Table 3.

Association Between a Sustained Virological Response to Hepatitis C Virus Treatment at 12 Weeks Posttherapy and Progression of Liver Disease, as Measured by the Aspartate Aminotransferase:Platelet Ratio Index, Canadian Co-Infection Cohort Study, 2003–2014

Variable	Model
	Naive MSMa		Direct SIMEX Correction		Indirect SIMEX Correction
	$\hat{\beta }$	95% CIb	$\hat{\beta }$	95% CI	$\hat{\beta }$	95% CI
SVR at third posttreatment visit	−0.26	−0.40, −0.11	−0.19	−0.38, −0.01	−0.17	−0.36, 0.01
Female sex	−0.09	−0.25, 0.09	−0.12	−0.32, 0.07	−0.08	−0.29, 0.10
Age, per 10 years	−0.07	−0.18, 0.03	−0.09	−0.21, 0.03	−0.08	−0.21, 0.04
Duration of HCV infection, per 10 years	0.03	−0.04, 0.09	0.02	−0.07, 0.11	0.03	−0.07, 0.12
HCV genotype of 2/3/4	0.00	−0.19, 0.19	0.02	−0.24, 0.28	−0.03	−0.26, 0.25

Abbreviations: CI, confidence interval; HCV, hepatitis C virus; MSM, marginal structural model; SIMEX, simulation-extrapolation; SVR, sustained virological response.

^a The naive MSM does not correct for measurement error in log₁₀(γ-glutamyltransferase).

^b All 95% CIs were computed by means of the nonparametric bootstrap percentiles approach.