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. 2016 May 18;63(4):539–547. doi: 10.1093/cid/ciw321

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© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

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Figure 3. — Cost-effectiveness of preexposure prophylaxis (PrEP) as a function of PrEP effectiveness and cost. These response surfaces show the incremental cost per life-year gained over lifetime in uncertainty analysis simulations of unprioritized (A) or age-prioritized (B) PrEP scale-up, compared with a reference scenario without PrEP. Risk-prioritized PrEP is not shown; it was cost-saving (reduced cost and increased life-years) in 84% of simulations. Inputs shown are the annual per-capita cost of PrEP and PrEP's effectiveness, defined as the product of its efficacy and reliability. Abbreviation: ICER, incremental cost-effectiveness ratio.