Table 3.

Selected Univariable and Multivariable Predictors of Significant Fibrosis (FIB-4 > 3.25)^a on Follow-up in Women Without Significant Fibrosis at Women's Interagency Human Immunodeficiency Virus Study Entry (n = 564)

Variable	Univariable Analysis		Multivariable Analysis
	HR (95% CI)	P Value	HR (95% CI)	P Value
Entry FIB-4 score	2.26 (1.88–2.73)	<.001	1.98 (1.62–2.42)	<.001
Black (Hispanic or African American) vs non-black race	0.78 (.61–.99)	.04b
Entry BMI	0.98 (.96–1.00)	.09
Entry log10 HCV RNA	1.19 (1.02–1.38)	.02	1.07 (.92–1.24)	.37
Baseline log10 HIV RNA load	1.18 (1.05–1.32)	.005b
Entry CD4	0.90 (.86–.95)	<.001	0.93 (.89–0.98)	.006
Entry tobacco use	1.37 (1.02–1.85)	.04b
Heavy entry alcohol use (>7 drinks/wk) vs abstainers	1.26 (.94–1.70)	.12
Risk per 1-drink increase in the weekly average	1.03 (1.02–1.04)	<.001	1.02 (1.01–1.03)	<.001
Risk per 1-use increase in average THC use per week	1.00 (.92–1.09)	1.00	1.01 (.92–1.10)	.83

Abbreviations: BMI, body mass index; CI, confidence interval; FIB-4, fibrosis 4; HCV, hepatitis C virus; HIV, human immunodeficiency virus; HR, hazard ratio; THC, tetrahydrocannabinol.

^a Cox proportional hazards regression, accounting for left truncation.

^b Not significant on multivariable analysis.