Table 2.
Treatment efficacy compared with drug placebo
| Number of trials (n=54)* | Number of patients (n=6652)* |
Mean YBOCS difference |
|||
|---|---|---|---|---|---|
| Full network (n=54) | Excluding waiting list controlled trials (n=48) | ||||
| Drug placebo | 23 | 1515 | Reference | Reference | |
| Waiting list | 6 | 97 | 5·62 (0·91 to 10·26) | NA | |
| Psychological placebo† | 6 | 196 | −4·15 (−8·65 to 0·49) | −1·90 (−5·62 to 1·91) | |
| SSRIs (class effect) | 37 | 3158 | −3·49 (−5·12 to −1·81) | −3·62 (−4·89 to −2·34) | |
| Fluoxetine | 6 | 633 | −3·46 (−5·27 to −1·58) | −3·67 (−5·13 to −2·26) | |
| Fluvoxamine | 13 | 521 | −3·60 (−5·29 to −1·95) | −3·66 (−4·96 to −2·37) | |
| Paroxetine | 8 | 902 | −3·42 (−5·10 to −1·61) | −3·51 (−4·81 to −2·14) | |
| Sertraline | 7 | 565 | −3·50 (−5·30 to −1·63) | −3·68 (−5·14 to −2·30) | |
| Citalopram | 2 | 311 | −3·49 (−5·62 to −1·31) | −3·60 (−5·25 to −1·91) | |
| Escitalopram | 1 | 226 | −3·48 (−5·61 to −1·23) | −3·59 (−5·25 to −1·86) | |
| Venlafaxine | 2 | 98 | −3·22 (−8·26 to 1·88) | −3·21 (−7·01 to 0·69) | |
| Clomipramine | 13 | 831 | −4·72 (−6·85 to −2·60) | −4·66 (−6·26 to −3·05) | |
| BT† | 11 | 287 | −14·48 (−18·61 to −10·23) | −10·41 (−14·04 to −6·77) | |
| CBT† | 9 | 231 | −5·37 (−9·10 to −1·63) | −7·98 (−11·02 to −4·93) | |
| Cognitive therapy† | 6 | 172 | −13·36 (−18·40 to −8·21) | −9·45 (−13·76 to −5·19) | |
| Hypericum | 1 | 30 | −0·15 (−7·46 to 7·12) | −0·13 (−5·93 to 5·68) | |
| CBT and fluvoxamine | 1 | 6 | −7·50 (−13·89 to −1·17) | −8·81 (−13·75 to −3·88) | |
| BT and clomipramine | 1 | 31 | −12·97 (−19·18 to −6·74) | −11·68 (−16·73 to −6·65) | |
Data in parentheses are 95% credible intervals. YBOCS=Yale-Brown Obsessive Compulsive Scale. BT=behavioural therapy. CBT=cognitive behavioural therapy. NA=not applicable.
*
Individual trials could be included in more than one treatment category.
†
Several patients randomly allocated into these psychotherapeutic interventions were allowed to take stable doses of antidepressants and remain on the same dose without further adjustments.