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Effects of 100 nM somatostatin on the cytoplasmic Ca2+ concentration in one big and two small islets after elevation of glucose in the presence of 1 mM tolbutamide. Exposure to somatostatin resulted in glucose-dependent oscillations mediated by periodic interruption of elevated Ca2+ in 42 of 47 of the small islets and in 4 of 13 of the big islets.
