Table 1.
Comparison between six other cases of MI associated with steroid use.
| Case | Ferenchick and Adelman [14] | Yildirim et al. [15] | Arslan et al. [16] |
Takamatsu et al. [17] | Owecki and Sowiński [18] | Poorzand et al. [2] |
|---|---|---|---|---|---|---|
| Age (years) | 37 | 64 | 20 | 79 | 66 | 23 |
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| Risk factors | Family history of CAD | HLD | Smoking (7 years) |
Bortezomib use | Smoking HLD |
|
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| Gender | Male | Male | Male | Female | Female | Male |
|
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| Steroid type | Nandrolone-decanoate, Boldenone, testosterone-cypionate, Stanozolol, and veterinary oxandrolone |
Prednisolone | Methylprednisolone | Dexamethasone | Methylprednisolone | Dexamethasone |
|
| ||||||
| Indication | Anabolic steroids (weightlifting) | Idiopathic intracranial HTN (papilledema) |
Anaphylaxis | Multiple myeloma |
Graves | Anabolic steroids (wrestling) |
|
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| Route | Intramuscular & oral | Oral | Intravenous | Intravenous | Intravenous | Intramuscular |
|
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| Dose | 200 mg/week for 16 weeks 1.5 cc q3 days/16 weeks 1.5 cc q4 days/16 weeks 1.5 cc q3 days/16 weeks 50 mg daily for 16 weeks |
40 mg daily |
40 mg | NA | 1 gm daily | NA |
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| Duration of use | Intermittent for 7 years and then 16 weeks before the event |
One month | 7 minutes | 5 days | 5 days | 6 months |
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| Possible confounders | Hypotension secondary to anaphylaxis | Bortezomib use | ||||
|
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| Acute coronary syndrome type | STEMI | NSTEMI and then STEMI few days later | STEMI | STEMI | NSTEMI | STEMI |
|
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| EKG | ST elevation, II, III, and aVF |
ST elevation, II, III, and aVF; ST depression, I, aVL |
ST elevation, I, aVL |
ST elevation, aVR; ST depression, I, II, and aVF V2–6 |
NA | ST elevation, I, aVL |
|
| ||||||
| Echo | Normal | Normal | EF 35% apical & posterolateral wall motion abnormality | EF 68% posterior & anterolateral akinesia |
Anteroseptal akinesia | EF 35% apical, midanterior, anteroseptal akinesia |
|
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| Left heart catheterization findings | Normal coronaries (3 days following tissue plasminogen activator) |
RCA: slow flow and then PDA total occlusion & LAD slow flow |
Normal coronaries 10 days later (normal IVUS) (treated with Aspirin & Heparin) |
LM/LCX significant lesions LAD mod stenosis | LAD total occlusion RCA critical stenosis | Nonobstructive CAD (4 days after streptokinase) |
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| Complications | LV thrombus | |||||