Figure 1.

Experimental daily scheme. Blue represents the two insulin administration modes. For the single injection group, 4 UI/200 g of body weight of long-acting insulin was administered each day at 9 am. Analyses were carried out at t + 5 and t + 22 h thereafter. For the continuous insulin administration group (via pumps), a rapid-acting insulin was loaded into the osmotic pump to allow a delivery of 4 UI/200 g of body weight per day. The injection point t0 corresponds to 9 am and analyses were carried out at t + 5 and t + 22 h thereafter.