Figure 1.

Immune Response Profiling of APS1/APECED

(A) Distributions of hits between patients and controls at different Z scores.

(B) Z scores for all samples against all protein features and mean hits for each group calculated for Z ≥ 3, Z ≥ 4, and Z ≥ 5. The number of distinct proteins targeted in each group (P, n = 97; C, n = 21) at Z scores denoted. The complexity factor was calculated by dividing the number of distinct proteins by average number of hits per patient.

(C) The max Z score distribution of all proteins in patient and control groups.

(D) Fraction of patients recognizing each of 3,731 proteins at Z ≥ 3. Red dots depict 126 proteins shared between patients and controls.