Figure S1.

Related to Figure 1

(A) Z scores for all samples against all protein features were calculated as described in experimental procedures and the mean hits for each group were calculated for either Z score ≥ 3, Z score ≥ 4, and Z score ≥ 5. There is a significant difference between patients and healthy relative and controls but no significant difference between healthy relatives and controls.

(B) Mean hits score for Z ≥ 3 were calculated for each geographical location. There is no significant difference between the patient cohorts but all cohorts are significantly different from the controls with the exception of the Slovenian and significantly different from the healthy relatives with exception of the Norwegian and Slovenian.

(C) Mean hits score for Z ≥ 3 were calculated for age-grouped patients with no significant difference between the groups.

Data are represented as mean ± SEM and statistical significance levels were calculated by Kruskal-Wallis testing.