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. 2016 Aug 1;3(4):ENEURO.0150-16.2016. doi: 10.1523/ENEURO.0150-16.2016

Figure 4.

Figure 4.

Active caspase-9 expression in hAPP-expressing OSNs of both OMP-hAPP and Camk2a-hAPP mice. A, B, Cleaved caspase-9 signal in the OE of 3-week-old OMP-hAPP, Camk2a-hAPP, and control animals (A) showed OSNs that were positive for caspase-9 signal and clearly colocalized with hAPP signal shown in both mutant lines (B). C, Quantification of caspase-9-positive cells showed a significant increase in both hAPP-expressing lines compared with the controls (Camk2a-hAPP, 16.7 ± 4.1, n = 4; and OMP-hAPP, 27.3 ± 7.0, n = 4; compared with tetO-hAPP, 7.4 ± 0.6, n = 4). D, In addition, relative expression levels of the apoptosis markers, active caspase-3, caspase-9, and BAX were all increased in the mutant lines compared with controls, while full-length caspase-3 and caspase-9 levels showed a small reduction in mutant lines compared with control, which is consistent with an increased conversion to their cleaved active forms. Scale bars: A, 100 µm; B, 20 µm. *p < 0.05.