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. 2016 Aug 1;3(4):ENEURO.0150-16.2016. doi: 10.1523/ENEURO.0150-16.2016

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Copyright © 2016 Cheng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Vital-dye staining indicates dysfunctional mitochondria in hAPP-expressing OSNs. A, Fluorescent images of olfactory epithelium from OMP-hAPP mutant mice (right panels) and tetO-hAPP controls (left panels) comparing in vivo mitochondrial staining via TMRE indicator (red) in OMP-GFP-positive OSNs (green). B, Close-up of boxed regions in A showing that OSNs from control mice (left) contain live mitochondria (white asterisks) that are also detectable in the OSN dendritic knobs (arrowhead). By comparison, OSNs from mutant mice (right) show little colocalization with TMRE signal both in cell bodies (black asterisks) and in dendritic knobs (arrows). Scale bars: A, 20 µm; B, 5 µm.