Skip to main content
. 2016 Aug 1;6:30800. doi: 10.1038/srep30800

Table 4. National Cancer Institute’s Pathway Interaction Database Analysis.

Pathway Proteins p value
Signaling events mediated by HDAC Class III CDKN1A, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4, TP53 6.22E-18
Glucocorticoid receptor regulatory network AKT1, CDKN1A, IFNG, IL4, IL6, IL8, KRT14, KRT17, KRT5, SFN, STAT1, TP53 6.73E-08
VEGFR1 specific signals AKT1, CALM1, CALM2, CALM3, NOS3, RASA1, VEGFA 1.52E-06
AP-1 transcription factor network BAG1, CCL2, IFNG, IL10, IL4, IL6, IL8, MMP9, TP53 9.53E-06
Caspase Cascade in Apoptosis AKT1, APAF1, ARHGDIB, GSN, RIPK1, TNF, VIM, XIAP 1.43E-05
Insulin-mediated glucose transport AKT1, CALM1, CALM2, CALM3, SFN, YWHAZ 1.84E-05
SHP2 signaling EGF, EGFR, IFNG, IL6, LCK, NOS3, STAT1, VEGFA 1.85E-05
a6b1 and a6b4 Integrin signaling AKT1, CDH1, EGF, EGFR, ERBB2, SFN, YWHAZ 2.94E-05
Angiopoietin receptor Tie2-mediated signaling AKT1, CDKN1A, FGF2, FYN, NOS3, RASA1, TNF 4.45E-05
ErbB1 downstream signaling AKT1, CALM1, CALM2, CALM3, EGF, EGFR, RALA, SFN, STAT1, YWHAZ 5.51E-05
IFN-gamma pathway AKT1, CALM1, CALM2, CALM3, IFNG, STAT1 1.80E-04
ErbB receptor signaling network EGF, EGFR, ERBB2, TGFA 2.31E-04
HIF-1-alpha transcription factor network AKT1, ALDOA, ENO1, PGK1, PKM, TF, VEGFA 3.18E-04
Calcium signaling in the CD4+ TCR pathway CALM1, CALM2, CALM3, IFNG, IL4 3.20E-04
LKB1 signaling events CTSD, EZR, MAPT, SFN, TP53, YWHAZ 3.29E-04
Ceramide signaling pathway AKT1, CTSD, EGF, EIF2AK2, RIPK1, TNF 3.68E-04
Direct p53 effectors APAF1, CDKN1A, CTSD, EGFR, HSPA1A, HSPA1B, PCNA, SFN, TGFA, TP53 3.82E-04
Signaling events mediated by PTP1B AKT1, EGF, EGFR, FYN, LCK, TXN 5.05E-04
Signaling events mediated by VEGFR1 and VEGFR2 AKT1, CALM1, CALM2, CALM3, FYN, NOS3, VEGFA 5.30E-04
EGF receptor (ErbB1) signaling pathway EGF, EGFR, GSN, RASA1, STAT1 5.66E-04