Figure 1. Human Prostate Cancer Hallmarks Map- A Hypothesis Driven Project.

(a) Prostate cancer at a glance- represents some basic facts around current prostate cancer treatment approach, its limitations and its associated post therapeutic complications. (b) Achilles’ heel in cancer- depicts three important factors and their underlying features that most fundamentally challenges and dampens current molecularly targeted therapies in cancer. (c) ‘Clausewitzian Dictum’ in cancer biology- Here we propose for a multi target strategy, ‘Clausewitzian Dictum’ that essentially calls for a three level targeting- attack at the network level, attack at the cancer hallmark level, and for functional modular level. On the other hand, these three factors-cancer protein interactome network, cancer hallmark functional ability and its modular signaling network architecture together comprises the Achilles’ heel in cancer. (d) Our Bottom Up Approach- Adaptor protein comprises our initial seed protein. Binary protein interaction database [Human Protein Reference Database (HRPD)] provides information for adaptor protein and its physical interacting partner. For accessing the role of adaptor protein and its binary interacting partner in the context of prostate cancer, we manually curated the literature for each of adaptor protein and its corresponding interacting partner. Based on these information, we reconstruct adaptor centric molecular interactome in human prostate cancer. For gaining a functional organizational view, we then extracts various oncogenic signaling pathways maps, subnetworks and modules associated with diverse cell biological events and hallmark related phenomenon with other literature mined information’s (detailed in the material and methods section). (e) Human Prostate Cancer Hallmarks Map Features- It provides a comprehensive resource for revealing molecular architecture of human prostate cancer at four specific levels namely, prostate cancer hallmark & its underlying feature based phenomenon, prostate cancer hallmark based and cell biological function based molecular connectivity map, hallmark based and its underlying events related oncogenic signaling pathway map, hallmark and inter hallmark related pathway based functional connectivity map.