Table 1. Content of Human Prostate Cancer Hallmarks Map.
Cancer Hallmarks/ Cell Bilogical Features | Molecular Components | Network Statistics |
Oncogenic Signaling Pathway | Pathway based Functional Connectivity Map | |
---|---|---|---|---|---|
Classical Cancer Hallmarks | Proteins | Nodes | Edges | Proteins | No of Connectivity Maps |
Evasion of growth suppression | 62 | 88 | 110 | 90 | 14 |
Sustaning proliferative signaling | 100 | 163 | 468 | 91 | 21 |
Tumour promoting inflammation | 12 | 23 | 63 | 29 | 16 |
Genome instability & Mutation | 56 | 56 | 125 | — | 19 |
Cell death resistance | 36 | 92 | 90 | 89 | 13 |
Angiogenesis | 23 | 43 | 41 | 42 | 15 |
Metastasis | 106 | 157 | 427 | 101 | 14 |
Metabolic reprogramming | 23 | — | — | 78 | — |
Avoidance of Immune Destruction | 22 | — | — | 43 | — |
Replicative Immortalization | 29 | — | — | 38 | — |
Tumour Microenvironment | 30 | — | — | 74 | — |
Prostate Cancer Unique Hallmarks | |||||
AR mediated signaling | 17 | 116 | 115 | 58 | — |
Androgen Independence | 29 | — | — | 143 | — |
Castration Resistance | 49 | — | — | 130 | — |
Cell Bilogical Features | |||||
Cell Cycle | 27 | — | — | 75 | — |
Tumour Suppression | 39 | — | — | 93 | — |
Cell Growth | 59 | 95 | 103 | 90 | 18 |
Cell Survival | 35 | 91 | 95 | 91 | 9 |
Cell Proliferation | 56 | 91 | 101 | 90 | 15 |
Chemoresistance | 7 | 37 | 32 | 37 | — |
Cell Migration | 46 | 82 | 93 | 82 | 18 |
Cell Motility | 33 | 68 | 89 | 66 | 18 |
Cell Adhesion | 21 | 41 | 42 | 40 | 4 |
Cell Invasion | 53 | 71 | 73 | 71 | 16 |
Bone Metastasis | 13 | 13 | 24 | — | 13 |
Epithelial Mesenchymal Transition (EMT) | 22 | 39 | 34 | 38 | — |
Node represents number of proteins and edge indicates number of binary (physical) interactions between the proteins present in network.