Table 1. Content of Human Prostate Cancer Hallmarks Map.

Cancer Hallmarks/ Cell Bilogical Features	Molecular Components	Network Statistics		Oncogenic Signaling Pathway	Pathway based Functional Connectivity Map
Classical Cancer Hallmarks	Proteins	Nodes	Edges	Proteins	No of Connectivity Maps
Evasion of growth suppression	62	88	110	90	14
Sustaning proliferative signaling	100	163	468	91	21
Tumour promoting inflammation	12	23	63	29	16
Genome instability & Mutation	56	56	125	—	19
Cell death resistance	36	92	90	89	13
Angiogenesis	23	43	41	42	15
Metastasis	106	157	427	101	14
Metabolic reprogramming	23	—	—	78	—
Avoidance of Immune Destruction	22	—	—	43	—
Replicative Immortalization	29	—	—	38	—
Tumour Microenvironment	30	—	—	74	—
Prostate Cancer Unique Hallmarks
AR mediated signaling	17	116	115	58	—
Androgen Independence	29	—	—	143	—
Castration Resistance	49	—	—	130	—
Cell Bilogical Features
Cell Cycle	27	—	—	75	—
Tumour Suppression	39	—	—	93	—
Cell Growth	59	95	103	90	18
Cell Survival	35	91	95	91	9
Cell Proliferation	56	91	101	90	15
Chemoresistance	7	37	32	37	—
Cell Migration	46	82	93	82	18
Cell Motility	33	68	89	66	18
Cell Adhesion	21	41	42	40	4
Cell Invasion	53	71	73	71	16
Bone Metastasis	13	13	24	—	13
Epithelial Mesenchymal Transition (EMT)	22	39	34	38	—

Node represents number of proteins and edge indicates number of binary (physical) interactions between the proteins present in network.