Table 2. Molecular components of Human Prostate Cancer Hallmarks Map.
Cancer Hallmarks/Cell Bilogical Features | Total Proteins(Intrinsic Components) | Adaptors | Receptors | Kinases | Enzymes | Transcription Factors & Regulators | Other Signaling Proteins | Last Update |
---|---|---|---|---|---|---|---|---|
Classical Cancer Hallmarks | ||||||||
Evasion of growth suppression | 62 | 9 | 8 | 4 | 4 | 16 | 21 | 2015 |
Sustaning proliferative signaling | 100 | 23 | 25 | 18 | 6 | 14 | 14 | 2015 |
Tumour promoting inflammation | 12 | 2 | 5 | — | — | 3 | 2 | 2015 |
Genome instability & Mutation | 56 | 16 | 14 | 5 | — | 8 | 13 | 2015 |
Cell death resistance | 36 | 14 | 8 | 5 | 2 | 4 | 3 | 2015 |
Angiogenesis | 23 | 1 | 8 | 6 | — | 4 | 4 | 2015 |
Metastasis | 106 | 18 | 20 | 14 | 5 | 22 | 27 | 2015 |
Metabolic reprogramming | 23 | 4 | 2 | 3 | 3 | 2 | 9 | 2015 |
Avoidance of Immune Destruction | 22 | — | 4 | — | 2 | 3 | 13 | 2015 |
Replicative Immortalization | 29 | 1 | 4 | 3 | 3 | 9 | 9 | 2015 |
Tumour Microenvironment | 30 | 1 | 8 | 1 | 5 | 3 | 12 | 2015 |
Prostate Cancer Unique Hallmarks | ||||||||
AR mediated signaling | 17 | 1 | 4 | 4 | 1 | 5 | 2 | 2015 |
Androgen Independence | 29 | 3 | 7 | 3 | 3 | 4 | 9 | 2015 |
Castration Resistance | 49 | 5 | 7 | 9 | 5 | 9 | 14 | 2015 |
Cell Biological Features | ||||||||
Cell Cycle | 27 | 5 | 2 | 3 | 1 | 4 | 12 | 2015 |
Tumour Suppression | 39 | 5 | 5 | 1 | 3 | 12 | 13 | 2015 |
Cell Growth | 59 | 10 | 17 | 14 | 3 | 7 | 8 | 2015 |
Cell Survival | 35 | 9 | 11 | 7 | 1 | 3 | 4 | 2015 |
Cell Proliferation | 56 | 12 | 11 | 6 | 3 | 8 | 16 | 2015 |
Chemoresistance | 7 | 3 | 1 | 1 | — | 1 | 1 | 2015 |
Cell Migration | 46 | 10 | 12 | 5 | 1 | 10 | 8 | 2015 |
Cell Motility | 33 | 8 | 5 | 7 | 1 | 4 | 8 | 2015 |
Cell Adhesion | 21 | 5 | 6 | 1 | — | 1 | 8 | 2015 |
Cell Invasion | 53 | 10 | 11 | 7 | 2 | 10 | 13 | 2015 |
Epithelial Mesenchymal Transition (EMT) | 22 | — | 5 | 2 | 2 | 7 | 6 | 2015 |
Bone Metastasis | 13 | — | 7 | 2 | — | 2 | 2 | 2015 |