Table 2. Molecular components of Human Prostate Cancer Hallmarks Map.
| Cancer Hallmarks/Cell Bilogical Features | Total Proteins(Intrinsic Components) | Adaptors | Receptors | Kinases | Enzymes | Transcription Factors & Regulators | Other Signaling Proteins | Last Update |
|---|---|---|---|---|---|---|---|---|
| Classical Cancer Hallmarks | ||||||||
| Evasion of growth suppression | 62 | 9 | 8 | 4 | 4 | 16 | 21 | 2015 |
| Sustaning proliferative signaling | 100 | 23 | 25 | 18 | 6 | 14 | 14 | 2015 |
| Tumour promoting inflammation | 12 | 2 | 5 | — | — | 3 | 2 | 2015 |
| Genome instability & Mutation | 56 | 16 | 14 | 5 | — | 8 | 13 | 2015 |
| Cell death resistance | 36 | 14 | 8 | 5 | 2 | 4 | 3 | 2015 |
| Angiogenesis | 23 | 1 | 8 | 6 | — | 4 | 4 | 2015 |
| Metastasis | 106 | 18 | 20 | 14 | 5 | 22 | 27 | 2015 |
| Metabolic reprogramming | 23 | 4 | 2 | 3 | 3 | 2 | 9 | 2015 |
| Avoidance of Immune Destruction | 22 | — | 4 | — | 2 | 3 | 13 | 2015 |
| Replicative Immortalization | 29 | 1 | 4 | 3 | 3 | 9 | 9 | 2015 |
| Tumour Microenvironment | 30 | 1 | 8 | 1 | 5 | 3 | 12 | 2015 |
| Prostate Cancer Unique Hallmarks | ||||||||
| AR mediated signaling | 17 | 1 | 4 | 4 | 1 | 5 | 2 | 2015 |
| Androgen Independence | 29 | 3 | 7 | 3 | 3 | 4 | 9 | 2015 |
| Castration Resistance | 49 | 5 | 7 | 9 | 5 | 9 | 14 | 2015 |
| Cell Biological Features | ||||||||
| Cell Cycle | 27 | 5 | 2 | 3 | 1 | 4 | 12 | 2015 |
| Tumour Suppression | 39 | 5 | 5 | 1 | 3 | 12 | 13 | 2015 |
| Cell Growth | 59 | 10 | 17 | 14 | 3 | 7 | 8 | 2015 |
| Cell Survival | 35 | 9 | 11 | 7 | 1 | 3 | 4 | 2015 |
| Cell Proliferation | 56 | 12 | 11 | 6 | 3 | 8 | 16 | 2015 |
| Chemoresistance | 7 | 3 | 1 | 1 | — | 1 | 1 | 2015 |
| Cell Migration | 46 | 10 | 12 | 5 | 1 | 10 | 8 | 2015 |
| Cell Motility | 33 | 8 | 5 | 7 | 1 | 4 | 8 | 2015 |
| Cell Adhesion | 21 | 5 | 6 | 1 | — | 1 | 8 | 2015 |
| Cell Invasion | 53 | 10 | 11 | 7 | 2 | 10 | 13 | 2015 |
| Epithelial Mesenchymal Transition (EMT) | 22 | — | 5 | 2 | 2 | 7 | 6 | 2015 |
| Bone Metastasis | 13 | — | 7 | 2 | — | 2 | 2 | 2015 |