Table 3. Oncogenic signaling pathway map statistics.
Cancer Hallmarks/Cell Bilogical Features | Total Proteins | Adaptors | Receptors | Transcription Factors & Regulators | OtherSignaling Proteins | Oncogenes | TumourSuppressor Proteins | Modulators | Gene expressions | References |
---|---|---|---|---|---|---|---|---|---|---|
Classical Cancer Hallmarks | ||||||||||
Evasion of growth suppression | 90 | 10 | 14 | — | 66 | 14 | 19 | 6 | — | 24 |
Sustaning proliferative signaling | 91 | 6 | 8 | 12 | 65 | 17 | 3 | 14 | 30 | 36 |
Tumour promoting inflammation | 29 | 3 | 5 | 3 | 18 | 5 | 2 | 3 | 1 | 9 |
Cell death resistance | 89 | 13 | 11 | 11 | 54 | 15 | 7 | 5 | 16 | 24 |
Angiogenesis | 42 | 4 | 10 | 5 | 23 | 7 | 3 | 2 | 7 | 18 |
Metastasis | 101 | 11 | 24 | 17 | 49 | 16 | 5 | 5 | 27 | 45 |
Metabolic reprogramming | 78 | 3 | 16 | 5 | 54 | 15 | 8 | 17 | 12 | 47 |
Avoidance of Immune Destruction | 43 | 1 | 9 | 3 | 30 | 6 | 1 | 2 | 17 | 21 |
Replicative Immortalization | 38 | 2 | 3 | 9 | 24 | 7 | 7 | 7 | 3 | 27 |
Tumour Microenvironment | 73 | 3 | 19 | 9 | 42 | 9 | 1 | 6 | 12 | 37 |
Prostate Cancer Unique Hallmarks | ||||||||||
AR mediated signaling | 58 | 6 | 4 | 7 | 41 | 9 | 2 | 7 | 16 | 23 |
Androgen Independence | 143 | 8 | 18 | 27 | 90 | 25 | 10 | 23 | 22 | 54 |
Castration Resistance | 130 | 7 | 12 | 21 | 90 | 18 | 4 | 11 | 29 | 63 |
Cell Biological Features | ||||||||||
Cell Cycle | 75 | 4 | 9 | 14 | 48 | 14 | 6 | 2 | 13 | 36 |
Tumour Suppression | 93 | 4 | 9 | 0 | 80 | 14 | 56 | 3 | 0 | 45 |
Cell Growth | 90 | 8 | 12 | 11 | 59 | 22 | 3 | 6 | 21 | 47 |
Cell Survival | 91 | 5 | 20 | 12 | 54 | 19 | 4 | 6 | 23 | 47 |
Cell Proliferation | 90 | 10 | 15 | 9 | 56 | 17 | 7 | 5 | 18 | 58 |
Chemoresistance | 37 | 2 | 9 | 7 | 19 | 14 | 3 | 4 | 12 | 19 |
Cell Migration | 82 | 13 | 18 | 11 | 40 | 14 | 7 | 5 | 12 | 53 |
Cell Motility | 66 | 9 | 16 | 6 | 35 | 18 | 3 | 3 | 12 | 28 |
Cell Adhesion | 40 | 10 | 10 | 2 | 18 | 7 | 2 | 6 | 6 | 20 |
Cell Invasion | 71 | 11 | 17 | 11 | 32 | 19 | 7 | 9 | 15 | 50 |
Epithelial Mesenchymal Transition (EMT) | 38 | 3 | 5 | 9 | 21 | 11 | 2 | 8 | 7 | 16 |