Table 3. Oncogenic signaling pathway map statistics.

Cancer Hallmarks/Cell Bilogical Features	Total Proteins	Adaptors	Receptors	Transcription Factors & Regulators	OtherSignaling Proteins	Oncogenes	TumourSuppressor Proteins	Modulators	Gene expressions	References
Classical Cancer Hallmarks
Evasion of growth suppression	90	10	14	—	66	14	19	6	—	24
Sustaning proliferative signaling	91	6	8	12	65	17	3	14	30	36
Tumour promoting inflammation	29	3	5	3	18	5	2	3	1	9
Cell death resistance	89	13	11	11	54	15	7	5	16	24
Angiogenesis	42	4	10	5	23	7	3	2	7	18
Metastasis	101	11	24	17	49	16	5	5	27	45
Metabolic reprogramming	78	3	16	5	54	15	8	17	12	47
Avoidance of Immune Destruction	43	1	9	3	30	6	1	2	17	21
Replicative Immortalization	38	2	3	9	24	7	7	7	3	27
Tumour Microenvironment	73	3	19	9	42	9	1	6	12	37
Prostate Cancer Unique Hallmarks
AR mediated signaling	58	6	4	7	41	9	2	7	16	23
Androgen Independence	143	8	18	27	90	25	10	23	22	54
Castration Resistance	130	7	12	21	90	18	4	11	29	63
Cell Biological Features
Cell Cycle	75	4	9	14	48	14	6	2	13	36
Tumour Suppression	93	4	9	0	80	14	56	3	0	45
Cell Growth	90	8	12	11	59	22	3	6	21	47
Cell Survival	91	5	20	12	54	19	4	6	23	47
Cell Proliferation	90	10	15	9	56	17	7	5	18	58
Chemoresistance	37	2	9	7	19	14	3	4	12	19
Cell Migration	82	13	18	11	40	14	7	5	12	53
Cell Motility	66	9	16	6	35	18	3	3	12	28
Cell Adhesion	40	10	10	2	18	7	2	6	6	20
Cell Invasion	71	11	17	11	32	19	7	9	15	50
Epithelial Mesenchymal Transition (EMT)	38	3	5	9	21	11	2	8	7	16