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. 2016 Aug 1;6:30636. doi: 10.1038/srep30636

Figure 7. WAS patient spleen NK cells have altered receptor expression.

Figure 7

(A) CD56 expression on healthy PBMCs, healthy splenocytes, and WAS patient splenocytes, plotted against CD3 in the plots and as MFI in the histograms. (B) CD69 and DNAM-1 surface expression, and Granzyme B and Perforin intracellular content in healthy PBMCs, healthy splenocytes, and WAS patient splenocytes. (C) Degranulation, as measured by CD107a surface expression and IFNγ production in healthy PBMCs, healthy splenocytes, and WAS patient splenocytes shown in contour plots (left) and a bar graph (right). (D–F) Expression analysis and survival of neuroblastoma patients in the R2 database, (R2: Genomics Analysis and Visualization Platform; http://r2.amc.nl). n = 498 (D) Correlation of WASp and IL-2 expression in neuroblastoma patients. Each patient is represented by circles for WASp expression (black circle; left Y-axis) and IL-2 expression (grey circle; right Y-axis). (E,F) Survival curves of (E) neuroblastoma patients and (F) diffuse large B cell lymphoma patients with high WASp expression (blue) and low WASp expression (red). Survival curves of (E) neuroblastoma patients and (F) diffuse large B cell lymphoma patients with high IL-2 expression (blue) and low IL-2 expression (red).