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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Biotechnol Bioeng. 2015 Aug 26;113(1):241–246. doi: 10.1002/bit.25700

Figure 4. Main physiological liver parameters replicated in the microtissue over a period of 28 days.

Figure 4

(a) Hepatocyte co-cultures under continuous flow of media have higher and more stable albumin secretion. (b) Urea secretion was 2-fold higher in the first days of flow stimulation and remained higher during the next 25 days of culture. (c) CYP3A4 activity was maintained during the four weeks and was similar in both static and flow conditions. n=3. Data are presented as mean ± SEM, n = 6-9 devices derived from 3 different experiments. A significant effect of flow was found for albumin (P < 0.001) and urea (P < 0.001).