Table 2.
Gastric emptying measured by 13C-octanoic acid breath test: baseline vs. post study drug comparison
| 13C-octanoic acid breath test parameters | Comparison | Baseline (mean) | Post study drug (mean) | Point estimate | 95 % CI |
|---|---|---|---|---|---|
| BTt½ (min)* | 50 mg (n = 15) | 117 | 76 | 0.65 | (0.39, 1.08) |
| 50 mg (n = 13)# | 121 | 65 | 0.54 | (0.32, 0.91) | |
| 75 mg (n = 6) | 46 | 85 | 1.85 | (0.82, 4.15) | |
| Placebo (n = 12) | 57 | 69 | 1.21 | (0.68, 2.15) | |
| GEC | 50 mg (n = 15) | 2.51 | 2.82 | 0.31 | (−0.16, 0.77) |
| 50 mg (n = 13)# | 2.51 | 3.05 | 0.55 | (0.09, 1.00) | |
| 75 mg (n = 6) | 3.09 | 2.60 | −0.49 | (−1.23, 0.25) | |
| Placebo (n = 12) | 2.90 | 2.83 | −0.06 | (−0.58, 0.46) |
Least squares means and point estimates are geometric least squares means and ratios for log-transformed parameters. #Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects
BTt½ breath test gastric time to half emptying, GEC gastric emptying coefficient
*Log-transformed