Table 4.
Acetaminophen absorption: post-dose vs. baseline comparison (excluding the n = 2 without adequate camicinal exposures)
| Plasma acetaminophen | Comparison | Baseline | Post study drug | Point estimate | 95 % CI |
|---|---|---|---|---|---|
| (mean) | (mean) | ||||
| C60 (ug/mL)* | 50 mg (n = 15) | 4.308 | 6.741 | 1.565 | (0.962, 2.545) |
| 50 mg (n = 13)# | 4.708 | 7.043 | 1.496 | (0.874, 2.560) | |
| 75 mg (n = 6) | 5.398 | 6.315 | 1.170 | (0.568, 2.409) | |
| Placebo (n = 12) | 6.291 | 6.609 | 1.051 | (0.630, 1.751) | |
| AUC(0–60) (ug.min/mL)* | 50 mg (n = 15) | 159.31 | 256.93 | 1.61 | (0.97, 2.67) |
| 50 mg (n = 13)# | 169.80 | 293.52 | 1.73 | (0.99, 3.03) | |
| 75 mg (n = 6) | 210.81 | 239.86 | 1.14 | (0.54, 2.41) | |
| Placebo (n = 12) | 224.21 | 230.08 | 1.03 | (0.60, 1.74) |
CI confidence interval, AUC area under the curve
*Log-transformed
#Two subjects administered 50 mg camicinal had low drug exposure. Analyses were performed with and without these subjects