Table 3.

Secondary Pain Measures Analysis

Pain Measure	Effect		Mean Difference	Standard Error	Confidence Interval		P Value
Unpleasantness	Basic analgesia pattern, placebo	Time, linear term	23.67	8.42	7.16	40.18	< .01
		Time, quadratic	0.14	0.050	0.044	0.23	< .01
	Treatment effect, interaction by time	3.5% vs placebo	−0.21	0.06	−0.33	−0.09	< .01
		7% vs Placebo	−0.21	0.06	−0.33	−0.09	< .01
Global impression of change	Basic analgesia pattern, placebo	Time, linear term	−22.62	4.04	−30.53	−14.70	< .01
		Time, quadratic	−0.13	0.023	−0.18	−0.08435	< .01
	Treatment effect, interaction by time	3.5% vs placebo	0.12	0.029	0.064	0.18	< .01
		7% vs Placebo	0.12	0.029	0.065	0.18	< .01
Allodynia	Basic pattern	Time, linear term	3.66	3.66	−3.50203	10.83	.32
		Time, quadratic	0.022	0.021	−0.01938	0.063	.30
	Treatment effect, interaction by time	3.5% vs placebo	0.00007	0.034	−0.066	0.066	.99
		7% vs placebo	−0.009	0.034	−0.076	0.058	.79
Heat stimuli	Basic pattern	Time, linear term	−2.64	6.52	−15.42	10.14	.69
		Time, quadratic	−0.015	0.038	−0.089	0.059	.69
	Treatment effect, interaction by time	3.5% vs placebo	0.11	0.06	−0.0046	0.23	.06
		7% vs placebo	0.085	0.060	−0.034	0.20392	.16

NOTE. Significant results (P < .05) are bolded.