Table 2. Results of per protocol and intention to treat analyses at month 18.
| Per protocol analysis, n=76 | Intention to treat analysis, n=126 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables |
Baseline mean (SD) |
Month 18 mean (SD) | P-value | Mean difference (95% CI) | P-value | Baseline mean (SD) | Month 18 mean (SD) | P-value |
Mean difference (95% CI) |
P-value |
| Serum creatinine (mg/dl) | 1.06 (0.3) |
0.94 (0.2) |
0.001 | -0.01** [-0.01 to 0.003] |
<0.001 | 1.08 (0.3) |
0.95 (0.2) |
<0.001 | -0.01** [-0.01 to -0.003] |
<0.001 |
| eGFR (ml/min/1.73m2) | 86.8 (33) |
96.4 (37) |
0.002 | 0.41** [0.21 to 0.61] |
<0.001 | 86.9 (24) |
95.8 (20) |
<0.001 | 0.42** [0.26 to 0.58] |
<0.001 |
| Total cholesterol (mg/dl) | 188 (42) |
206 (44) |
<0.001 | 0.86** [0.40 to 1.32] |
<0.001 | 187 (44) |
203 (44) |
<0.001 | 0.71** [0.31 to 1.10] |
<0.001 |
| HDL cholesterol (mg/dl) | 46 (14) |
54 (19) |
0.005 | 0.36** [0.13 to 0.59] |
0.015 | 46 (15) |
52 (17) |
0.002 | 0.28** [0.11 to 0.46] |
0.002 |
| Triglycerides (mg/dl) | 162 (144) |
214 (109) |
0.004 | 2.26** [0.26 to 4.25] |
0.027 | 168 (125) |
201 (199) |
0.114 | 1.21** [-0.29 to2.72] |
0.154 |
S.D.: standard deviation, eGFR: estimated glomerular filtration rate Adjusted for age, CD4+T cell count and risk factor for HIV infection