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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Top Magn Reson Imaging. 2016 Feb;25(1):31–37. doi: 10.1097/RMR.0000000000000076

FIGURE 2.

FIGURE 2

Pyruvate metabolism in preclinical animal model. Hyperpolarized [1-13C] pyruvate is preferentially metabolized to lactate in the anesthesized rat brain. Metabolic maps of lactate, alanine, and pyruvate are shown in the top row. The left lower panel shows 1H anatomic imaging. The right lower panel shows the source magnetic resonance spectroscopic imaging (MRSI), with individual resonances corresponding to pyruvate and its metabolic product, lacatate. Reproduced with permission from Magn Reson Med 2010; 63:1137–1143.