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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Psychoneuroendocrinology. 2015 Dec 23;65:109–117. doi: 10.1016/j.psyneuen.2015.12.004

Figure 2. Chronic stress in adolescence leads to stress-induced hypo-secretion of ACTH and CORT in adulthood.

Figure 2

A) Adolescent female rats exposed to CVS show reductions in ACTH secretion at the 5 min time-point compared to age-matched non-stressed controls. Similarly, adult female rats previously exposed to CVS show reductions in ACTH secretion at the 5min time-point compared to age-matched non-stressed controls. B) Adult rats with a history of CVS had significantly reduced CORT secretion in response to FST at the 30min time-point when compared to age-matched controls. Adolescent rats demonstrate lower CORT secretion at the 5min and 30 min time-point relative to their adult counterparts. C) CVS exposure leads to an increase in CORT baseline only in the adolescent animals when compared to control non-stressed adolescent rats. Adolescent control female rats have lower baseline secretion of CORT relative to their adult counterparts. # p<0.05 significant effect of stress within age group, ^p<0.05 significant effect of age within stress group. Data presented as mean ± SEM, n=10–12.