Table 17.
Potency of PAC-1, WF-208, and WF-210 against a diverse array of human cancer cell lines in culture. [48, 49]
| 72h IC50 (μM) | ||||
|---|---|---|---|---|
| Cell Line | Origin | PAC-1 | WF-208 | WF-210 |
| A549 | Lung | 25.48 | 0.42 | 1.78 |
| COLO205 | Colon | 11.46 | 12.85 | 1.1 |
| DU145 | Prostate | 26.03 | 0.08 | 0.08 |
| GBC-SD | Gallbladder | 53.44 | 0.08 | 0.08 |
| Hep 3B | Liver | 25.48 | 0.98 | 0.86 |
| Hep G2 | Liver | 16.35 | 0.73 | 0.22 |
| HGC-27 | Gastric | 13.18 | 0.52 | 0.99 |
| HL-60 | Leukemia | 4.03 | 0.08 | 0.08 |
| K-562 | Leukemia | 14.55 | 0.20 | 0.22 |
| MCF7 | Breast | 12.65 | 0.32 | 2.8 |
| MDA-MB-435S | Melanoma | 14.49 | 0.76 | 1.24 |
| NCI-H226 | Lung | 28.74 | 4.59 | 2.58 |
| U-87 MG | Glioblastoma | 8.82 | 1.67 | 1.05 |
| PC-3 | Prostate | 20.13 | 1.28 | 0.08 |
| U-937 | Lymphoma | 16.42 | 0.08 | 0.08 |