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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Curr Med Chem. 2016;23(3):201–241. doi: 10.2174/0929867323666151127201829

Table 7.

Structure and cytotoxicity of oxadiazole-containing PAC-1 derivatives. [48, 49]

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Compound R1 R2 HL-60 72h IC50 (μM)
27a 4-Cl 3-All 0.25
27b 4-F 3-All 0.39
27c 3-Cl 3-All 0.40
27d 2-CF3 3-All 0.35
27e 4-Cl 4-OBn 1.26
27f 4-F 4-OCH2(2,4-Cl2-Ph) 1.02
27g 4-F 4-OCH2(3-CF3-Ph) 0.98
27h 4-Cl 4-OCH2(4-t-Bu-Ph) 0.67
27i 4-Cl 4-OCH2(2,4-Cl2-Ph) 1.07
27j 4-F 4-OCH2(4-t-Bu-Ph) 0.60
27k 3,4-F2 4-OBn 0.34
27l 3,4-F2 4-OCH2(4-Cl-Ph) 0.30
27m 3,4-F2 4-OCH2(2,4-Cl2-Ph) 0.41
27n 2-CF3 4-OCH2(4-t-Bu-Ph) 0.40
27o 2-CF3 4-OCH2(3-F-Ph) 1.93
27p 4-Cl 4-OCH2(3-Cl-Ph) > 20
27q 2-CF3 - 1.08
27r (WF-208) 4-Cl - 0.08
27s (WF-210) 4-F - 0.08
PAC-1 - - 4.03