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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Alzheimers Dis. 2016;52(1):359–371. doi: 10.3233/JAD-151105

Figure 1. p53 protein levels and post-translational modifications.

Figure 1

p53 phosphorylation at Ser-20 (1)(ph.), acetylation at Lys382 (K382) (2)(ac.) and total expression (exp.) levels (3)were measured by Western Blot in the frontal cortex of controls and DS cases (Panel A) and in the frontal cortex of Ts65Dn mice at 6 and 12 months of age (T6, T12) compared to age-matched euploid animals (E6, E12 -Panel B). Densitometric values shown in the bargraph are the mean of 8 samples per group normalized to total protein load and are given as percentage of control (E6 mice), set as 100%. On the top a representative blot image with protein bands is shown (*p < 0.05).