Table 5.

Time lag between filing date of dosage-related patent and onset of clinical trials (when the dosage was actually established).

Patent Number	Subject matter	Priority date	Approval date	Studies	Study timeline	Delay between priority date and study onset
EP1616572B1	Rituximab for treatment of CLL	Nov. 9, 1998	Feb. 27, 2009 (EMA)	ML17102/CLL8 (NCT00281918) BO17072/Reach(NCT00090051)	First received: Jan. 24, 2006 Last verified: Sept. 9, 2013 First received: Aug. 23, 2004 Last verified: May 2013	8 years
EP2459167B1	Trastuzumab for breast cancer, sc administration	July 31, 2009	Sept. 2, 2013 (EMA)	HannaH(NCT00950300)	First received: July 30, 2009 Last verified: March 2016	−1 day