Table 3.
Geometric mean (CV%) of the pharmacokinetic parameters of GNbAC1 by doses following a single infusion with dose normalized values for Cmax and AUC.
| Parameter | 6 mg/kg (n=5) | 18 mg/kg (n=5) | 36 mg/kg (n=5) |
|---|---|---|---|
| AUC0tlast (µg·h/mL) | 57188 (24.5) | 169392 (18.0) | 335204 (8.8) |
| AUC0∞ (µg·h/mL) | 71465 (31.8) | 220723 (33.0) | 411381 (13.9) |
| Cmax (µg/mL) | 178.0 (8.6) | 452.3 (13.5) | 1018.5 (9.8) |
| tmaxa (h) | 2.02 (1.05-3.05) | 3.02 (2.05-8.02) | 4.06 (4.05-4.10) |
| t1/2 (h) | 500.4 (28.5) | 620.8 (40.3) | 606.0 (10.7) |
| MRT (h) | 682.0 (28.4) | 870.9 (39.1) | 783.1 (11.6) |
| CL (mL/h/kg) | 0.084 (31.8) | 0.082 (33.0) | 0.088 (13.9) |
| Vz (mL/kg) | 60.6 (6.8) | 73.0 (9.6) | 76.5 (6.7) |
| Dose norm AUC0tlast (µg·h/mL) | 9531.4 | 9410.6 | 9311.2 |
| Dose norm AUC0∞ (µg·h/mL) | 11910.9 | 12262.4 | 11427.3 |
| Dose norm Cmax (µg/mL) | 29.7 | 25.1 | 28.3 |
a
Median (range)