Table 2.
Target-related parameters. Receptor numbers are from Mazor et al.6
| CD4 |
CD70 |
|||
|---|---|---|---|---|
| Parameter | Per cell | Per cuboid | Per cell | Per cuboid |
| Receptors on CD4+/CD70+ cells | 82000 | 26 | 92000 | 29 |
| Receptors on CD4+/CD70- cells | 68000 | 22 | 0 | 0 |
| Receptors on CD4−/CD70+ cells | 0 | 0 | 55000 | 17 |
| 1Diffusion coefficient D, cm2/s | 5×10−10 | 5×10−10 | ||
1
CD4 subpopulations of different mobility, characterized by D=1.14×10−8 cm2/s, D = 2.34×10−10 cm2/s and D = 3.31×10−11 cm2/s were measured by Zhan et al.,40 D = 5×10−10 cm2/s according to Pal et al.,41 D= (1.87–20.9)×10−10 cm2/s and D = 1.35×10−10 cm2/s according to Rawat et al.,43 D=5×10−9 cm2/s according to Baker et al.43 and D = 2.7×10−10 cm2/s according to Finnegan et al.44 mAb solution diffusion coefficient D = 4×10−7 cm2/s has been reported by Saltzman.45