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The IgG-ECD BsAbs show faster clearance than their respective parental mAbs, but the clearance of a Fc-EDC fusion protein is similar to Fc following administration to cynomolgus monkeys. The mean pharmacokinetic profiles of (A) G1 and G1-ECD; (B) G2 and G2-ECD; (C) G3 and G3-ECD; and (D) Fc and Fc-ECD following a single IV administration to cynomolgus monkeys. Data are the mean for 2 animals/timepoint for all molecules.
