Table 2.
Mean cynomolgus monkey pharmacokinetic parameters of the IgG-ECD and Fc-ECD molecules.
| Molecules | Dose (mg/kg) | Cmax (μg/mL) | AUC0-∞(hr*μg/mL) | Vss (mL/kg) | CL (mL/hr/kg) | T1/2 (hr) |
|---|---|---|---|---|---|---|
| G1 | 2 (n = 2) | 69.7 | 6615 | 40.9 | 0.30 | 37.2 |
| G1-ECD | 2 (n = 2) | 51.4 | 606 | 60.3 | 3.32 | 12.0 |
| G2 | 10 (n = 2) | 327.0 | 42344 | 39.4 | 0.24 | 143.3 |
| G2-ECD | 15 (n = 2) | 480.0 | 12532 | 56.7 | 1.23 | 39.9 |
| G3 | 2 (n = 2) | 68.6 | 7645 | 34.7 | 0.26 | 91.1 |
| G3-ECD | 2 (n = 2) | 78.4 | 1509 | 75.3 | 1.35 | 134.6 |
| Fc | 2 (n = 2) | 56.1 | 2841 | 86.3 | 0.70 | 91.6 |
| Fc-ECD | 2 (n = 2) | 61.0 | 2034 | 105.4 | 0.99 | 78.4 |
Cmax, maximal observed plasma or serum concentration; AUC0-∞, area under the plasma or serum concentration curve from zero to infinity; Vss, volume of distribution at steady state; CL, clearance; T1/2, elimination half-life. Time points included in the estimation of terminal T1/2: G1 336–600 hours post dose; G1-ECD 24–120 hours post dose; G2 576–648 hours post dose; G2-ECD 96–504 hours post dose; G3 432–672 hours post dose; G3-ECD 240–672 hours post dose; Fc and Fc-ECD 360–648 hours post dose.