Table 4.
Mean cynomolgus monkey pharmacokinetic parameters of the G1-ECD molecule following treatment with empty liposomes or liposomes containing clodronate.
| Treatment | Dose (mg/kg) | Cmax (μg/mL) | AUC0-∞ (hr*μg/mL) | Vss (mL/kg) | CL (mL/hr/kg) | T1/2 (hr) |
|---|---|---|---|---|---|---|
| Empty Liposomes | 2 (n = 2) | 45.9 | 828 | 57.4 | 2.42 | 17.9 |
| Clodronate Liposomes | 2 (n = 2) | 51.7 | 1250 | 47.8 | 1.60 | 18.5 |
Cmax, maximal observed plasma concentration; AUC0-∞, area under the plasma concentration curve from zero to infinity; Vss, volume of distribution at steady-state; CL, clearance; T1/2, elimination half-life. Time points included in the estimation of terminal T1/2: 24–168 hours post dose.