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. 2016 May 27;8(6):1064–1078. doi: 10.1080/19420862.2016.1193660

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Figure 1. — Panel of mAbs Used in Study. Interspecies CL for therapeutic mAbs. Panels A, B and C depict the 27 mAbs examined in this study, including 21 Pfizer mAbs (•) and 6 marketed mAbs () and the CL values (mL/hr/kg) for human (15/27), NHP (26/27), and WT mouse (17/27), respectively. Mean CL value are depicted for each species. Symbols depict definitive linear CL values (•), apparent linear CL values (▪) and non-linear (▴). Of the 27 collected mAbs: 24 are IgG1 and 3 are IgG2; 16 have soluble ligand targets, 9 have membrane bound targets, and 2 target both soluble and membrane bound receptor targets; 12 are fully human, 13 are humanized, and 2 are chimeric.

Inline graphic — Panel of mAbs Used in Study. Interspecies CL for therapeutic mAbs. Panels A, B and C depict the 27 mAbs examined in this study, including 21 Pfizer mAbs (•) and 6 marketed mAbs () and the CL values (mL/hr/kg) for human (15/27), NHP (26/27), and WT mouse (17/27), respectively. Mean CL value are depicted for each species. Symbols depict definitive linear CL values (•), apparent linear CL values (▪) and non-linear (▴). Of the 27 collected mAbs: 24 are IgG1 and 3 are IgG2; 16 have soluble ligand targets, 9 have membrane bound targets, and 2 target both soluble and membrane bound receptor targets; 12 are fully human, 13 are humanized, and 2 are chimeric.