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. 2016 May 27;8(6):1064–1078. doi: 10.1080/19420862.2016.1193660

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Figure 6. — Correlation of mAb CL in Rodents vs Human and NHP vs Human. Linear correlation graphs of (A) WT mouse CL to human CL for 11/27 mAbs, (B) NHP CL to human CL for 15/27 mAbs, (C) Tg32 hemizygous CL to human CL for 15/27 mAbs and D) Tg32 homozygous CL to human CL for 15/27 mAbs. MAbs shown in panels B, C, and D represent the same 15 mAbs. Tg32 mouse CL results are shown as the mean ± standard deviation for 3-6 animals/group. Symbols: •, definitive linear CL values; ▴, apparent linear CL in rodent or NHP; ▪apparent linear CL in human; ♦, apparent linear CL in rodent or NHP and human. •, Pfizer mAbs, , marketed therapeutic mAbs.

Inline graphic — Correlation of mAb CL in Rodents vs Human and NHP vs Human. Linear correlation graphs of (A) WT mouse CL to human CL for 11/27 mAbs, (B) NHP CL to human CL for 15/27 mAbs, (C) Tg32 hemizygous CL to human CL for 15/27 mAbs and D) Tg32 homozygous CL to human CL for 15/27 mAbs. MAbs shown in panels B, C, and D represent the same 15 mAbs. Tg32 mouse CL results are shown as the mean ± standard deviation for 3-6 animals/group. Symbols: •, definitive linear CL values; ▴, apparent linear CL in rodent or NHP; ▪apparent linear CL in human; ♦, apparent linear CL in rodent or NHP and human. •, Pfizer mAbs, , marketed therapeutic mAbs.