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. 2016 May 31;8(6):1136–1155. doi: 10.1080/19420862.2016.1193659

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 13. — Comparison of the biological activities of SB4 and the reference product obtained from the EU and US reference product. (A) Relative TNF binding activity as shown by FRET assays. (B) Relative LTα binding activity as shown by FRET assays. (C) Relative potency as indicated by a TNF neutralization assay. The dotted line indicates the similarity range (mean±kSD) based on results of etanercept obtained from the EU.