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Sequence alignment for trimethoprim-sensitive (SaWT and KpWT) and trimethoprim-resistant dihydrofolate reductases (DHFRs). S1 DHFR and S3 DHFR are found in Gram-positive bacteria. DfrA1, DfrA12, and DfrA17 are found in Gram-negative bacteria. Residues colored in red are located in the inhibitor-binding pocket. As Klebsiella pneumoniae and Escherichia coli sequences are almost identical, only one sequence is shown here.
