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. 2016 Aug;6(8):a028324. doi: 10.1101/cshperspect.a028324

Figure 4.

Figure 4.

Structural comparisons of wild-type and trimethoprim-resistant DHFR. Structural superposition of (A) Staphylococcus aureus (wild-type [wt]) (pink) bound to nicotinamide adenine dinucleotide phosphate (NADPH) (yellow) and trimethoprim (TMP) (blue) with S1 dihydrofolate reductase (DHFR) (green) bound to NADPH and TMP (not shown) (Heaslet et al. 2009), and (B) Klebsiella pneumoniae (wt) (dark blue) bound to NADPH (orange) and a propargyl-linked antifolate (PLA) (not shown) with DfrA1 (cyan) bound to NADPH and a PLA (green) (Lombardo et al. 2015).