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Loss of Grb14 impedes the transcriptional activation of LXR by its agonist T0901317. Mice injected with Grb14i or USi were subjected to oral gavage with T0901317 (T0; 50 mg/kg) or with vehicle (Vhc; 0.5% methylcellulose) 18 h before being sacrificed at day 7 postinfection. Liver gene expression was measured by qRT-PCR. Results are means ± SEM (n = 5 or 6 per group). *, P < 0.05; **, P < 0.01; ***, P < 0.005.
