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Putative roles of RINT1 in neuronal autophagy. RINT1-deficiency might disrupt the DYNEIN-DYNACTIN dependent-retrograde transport of the autophagosomes in neurons (1). RINT1 could play a role in the transport and maturation of lysosomal proteases such as though interaction with SEC22B (2) or in the membrane fusion of autophagosomes and lysosomes via interaction with the SNARE protein STX17 (3).
