Table 3.

Categorical Age Variable: Factors Predictive of Disease-Specific Survival on Cox Proportional Hazards Model

Variable	Unadjusted HR	95% CI	p value	Adjusted HR	95% CI	p value
Age at diagnosis (years)*
<40	reference			reference
40–49	1.88	0.38–9.34	0.439	2.093	0.42–10.4	0.367
50–59	8.59	2.45–30.18	0.001	14.34	3.89–52.88	<0.001
60–69	11.43	3.18–41.08	<0.001	21.52	5.61–82.52	<0.001
>70	76.43	23.1–252–92	<0.001	37.34	10.92–127.76	<0.001
Sex
Female	reference			reference
Male	2.93	1.75–4.89	<0.001	1.19	0.66–2.15	0.567
Pathology
Papillary Ca	reference			reference
Follicular Ca	2.86	1.22–6.71	0.015	4.32	1.56–11.95	0.005
Hürthle cell Ca	2.94	1.17–7.4	0.022	2.88	1.02–8.17	0.047
pT stage
T1	reference			reference
T2	1.04	0.33–3.32	0.95	0.93	0.28–3.06	0.9
T3	2.94	1.38–6.28	0.005	1.41	0.62–3.21	0.412
T4	19.3	9.26–40.3	<0.001	4.86	2.04–11.55	<0.001
pN stage
N0NX	reference			reference
N1a	1.48	0.68–3.2	0.325	1.99	0.80–4.93	0.14
N1b	3.6	2.0–6.3	<0.001	2.22	1.02–4.86	0.046
M stage
M0	reference			reference
M1	45.38	27.11–75.96	<0.001	17.79	9.63–32.85	<0.001

^*Age (categorical) adjusted for sex, pathology, and T, N, and M stage.