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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Sci Transl Med. 2015 Nov 11;7(313):313ra180. doi: 10.1126/scitranslmed.aac6191

Fig. 3. rAAV.caTPP1 treatment delays onset of cognitive deficits and increases life span of TPP1-deficient dogs.

Fig. 3

(A) Cognitive deficits were assessed by the T-maze (18) in rAAV.caTPP1-treated dogs (DC019 and DC020) and untreated dogs (DC024 and DC025) from 4 months (1 month after injection) onward (see also table S2). The asterisk denotes the last time point that dogs were capable of completing the T-maze because of motor impairment or behavioral problems. (B) Survival plot of untreated TPP1-deficient dogs (solid line) and rAAV.caTPP1-treated TPP1-deficient dogs (dashed and dotted lines). Mycophenolate mofetil treatment was initiated 33 days after vector delivery (dashed line) or 5 days before vector delivery (dotted line).