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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Oncogene. 2012 Aug 27;32(24):2907–2916. doi: 10.1038/onc.2012.350

Table 2.

Summary of FBP1 as a RNA-binding protein

Target Binding site Function Experimental model Reference
GAP34 3′-UTR GAP34 mRNA degradation Rat brain 9
p21 3′-UTR p21 mRNA degradation Hep3B cells 19,46
Cox-2 3′-UTR Unclear HeLa cells 54,66
p27 IRES in 5′-UTR Enhances protein translation MCF7 cells 15
NPM 3′-UTR Inhibits protein translation Tsc−/− p53−/− MEFs 61
HCV 3′-UTR Promotes viral replication MH14 cells 11
JEV 5′-UTR Suppresses protein translation/viral replication HeLa cells NT2 cells 8
EV71 IRES in 5′-UTR Enhances protein translation/viral replication SK-N-MC, SF268, RD and Vero cells 61

Abbreviations: FBP1, far upstream binding protein 1; HCV, hepatitis C virus; IRES, internal ribosomal entry site; JEV, Japanese encephalitis virus; NPM, nucleophosmin; UTR, untranslated region.